The innovation and clinical application of ischemia-free organ transplantation

The incidence rate of liver cancer is increasing year by globally. Liver transplantation has become one the therapeutic methods for patients with cancer. In past, ischemia-reperfusion injury (IRI) was unavoidable in transplantation, compromising recipient and graft survival. At same time, imbalance between supply demand organs limits use Recently, advances have been made machine perfusion techniques to reduce IRI. However, none can completely abrogate 2017, concept ischemia-free organ (IFOT) proposed, our group conducted first case (IFLT). We then extended IFOT kidney 2018 heart 2021. Here, we review history, strengths, weaknesses, future direction IFOT, particularly cancers.